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| Interactions: | Antacids Comb.
Adverse Effect: decreased nalidixic acid effectiveness Clinical Management: Concurrent administration of nalidixic acid and antacids is not recommended. If concurrent use cannot be avoided, nalidixic acid should be taken at least two hours before or six hours after antacids. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antibiotic efficacy.
Sucralfate
Adverse Effect: decreased nalidixic acid effectiveness Clinical Management: Concurrent administration of nalidixic acid and sucralfate is not recommended. If concurrent use cannot be avoided, nalidixic acid should be taken at least two hours before or six hours after sucralfate. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antibiotic efficacy.
Warfarin
Adverse Effect: an increased risk of bleeding Clinical Management: In patients receiving oral anticoagulant therapy with warfarin, anticoagulant response should be assessed with the prothrombin time ratio or international normalized ratio (INR) upon the addition and withdrawal of nalidixic acid. Warfarin dose should be adjusted accordingly to maintain the desired level of anticoagulation. |
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